The structural virology group in the Department of Biological Sciences at Purdue University consists of six different laboratories that use a combination of cryo-electron microscopy, crystallography, and molecular biology to elucidate the processes of viral entry, replication, and pathogenesis. One of the strengths of this group is the extensive network of collaborative efforts between the laboratories.
 
                                 

Jue Chen:
Biochemical and structural studies of Flavivirus entry mechanism.

Alan Friedman:
X-ray crystallography to study virus structure.

Richard J. Kuhn:
Molecular biology techniques to examine the process of virus replication, assembly and pathogenesis.

 

 

Carol Post:
NMR and molecular dynamics to examine virus assembly, uncoating, and the mechanisms of virus-drug interactions.

Michael Rossmann:
X-ray crystallographic techniques to probe the structure/function relationshiops of several viruses and their receptors.

David A. Sanders:
Studies of the entry of enveloped viruses into cells through membrane fusion and utilization of novel recombinant retroviruses for gene transfer and gene therapy.